Generally speaking, I must agree with all of you guys!
I have shot several deer over the years, while it was raining!
However, back when I was researching stuff about the 17 Remington for my brother, I read somewhere that it would be a waste of time and ammo to fire this cartridge in the rain!
This was due (supposedly) to the fact that the little 25 grain HP going at 4200fps would disintigrate if it were to hit a drop of water!
True or not, I don't have a clue!