I have a CZ550 in .458lott, and it does me quite fine. It handles the caliber fine, but it's not for any huge distances, just knocking the hell out of stuff. If you are going to be hunting bear/moose/elk, I would say that the .375 is great, which is what I use my .458 for, but anything quicker, more distance, I would recommend something smaller. Like a 300RUM, still gets the job done for anything not in africa, but the trajectory is better, and its a shitload less expensive for ammo. Haven't had any problems with my 550 though, smooth action, shoots straight, doesn't hop around at all, puts big holes in things. You could also look at the remington 700XCR, some of my buddies have them, and they are just sexy. I'm gonna buy one in the 300RUM next time I have $700 or so. You could also look at a .338 lapua mag, more militaries are starting to use it for sniping, amazing ballistics, but I haven't seen a whole lot of companies making a rifle for it. If you REALLY want to blow some money, and put some massive holes in things, and leave your shoulder out in the woods, and kill an elephant in one shot, you could get a .460 weatherby. I'm pretty sure weatherby is the only company that makes a rifle for it, and there is probably good reason for that. Rediculous would be a good word, but hey, you could shoot the rocks in front of a moose a 100 yards and still knock him dead.