Ive lived with 1 main center fire for 30 years, the 7mm Rem Mag. Ive added the 25-06 to my little group of firearms that does it all. The 7mm and the 25-06 would be my choice if I could only own 2 center fires.
I own a 45/70, 308, 7X57, 270 Win, 243 Win, 22-250, 220 Swift, 17 Rem. I would give them all up for the 7mm and the 25 (thankfully I dont have too at this time).