This is really a great psychological test, because it is plainly breaking people into two main groups.
The first group is concerned about having a true varmint round at bottom end (such as the .223 or .22 Hornet or .243), and a heavier all-purpose round at the top, such as the 30-06, or .308 or 7 Mag.
The second group is not so concerned with having a light rifle in a true varmint caliber at the bottom. They are more concerned with large animals in the middle and big time heavy weight animals at the top. The concept of varmints is almost an after thought. So, they are choosing a heavier but flexible caliber at the bottom (such as the 25-06 or .257 Roberts) and a really heavy but less flexible round at the top (such as the .338 mag or the .375 mag.)
I believe that the first group knows that not one in a ten thousand of us will ever get a chance to see, much less hunt, a big grizzly in the wild. They are practical and pragmatic. Accordingly, they are more driven by the fun of good varmint shooting, and they are not driven by the concept of "What about the truly big bears?" (Also, there seems to be a survivalist flavor here, with this group also being focused on easy ammo availability and military rounds.)
I believe that the second group are optimists and dreamers, and still think that one day, some day, somehow, they will confront a big grizzly in the wild, and that therefore they need that big top-end magnum to feel satisfied. Their focus is on the dream of big game hunting, regardless of easy ammo availability.
OK, the foregoing having been said, I fall into the first group. I like the 22 Hornet or .223 on the bottom, and a 30-06 or .308 on the top. (If I lived out west, I guess I would put the 7 Mag on the top.)
Let the screaming commence!
Big Paulie