I have never used that bullet, but I have used "X" bullets in 30/06, .270 and .22k hornet. The one issue that I have with them is their finicky nature. Some rifles love them, others hate them, and there is no middle ground...
I did just order 140gr for my 357max, 110gr for my 30/30s, and 250gr for my 45/70s. Here is to hoping that the Handys like them (which I think they will. Long throat seems to be the key).
Steve