I didn't buy my Handi's because I could switch barrels but because they are "cheap" in relation to other rifles as far a price goes and because they have other potentials to explore. I have so many other rifles and switch barrels for them, that NEF has very few calibers I'm interested in. It is the STUB barrel potential I'm interested in.
A stub barrel setup has the potential for ANY cartridge and caliber...within reason and the pressure parameters of the frame. Never seen much use for a pistol cartridge in a rifle except for maybe matching it to a carry pistol and even then I scratch my head, but if that's what you want and want to pay the price then go for it.
I've been swapping barrels since the 60's in/on Savage, Rem and Rugers, with and without barrel nuts. Some of my early Rem benchrest competition rifles had switch barrels AND switch bolts I could change between matches so I could shoot in several matches. It would take me about 10 minutes to swap one out...5 if I was in a hurry...
Today, all my Savages have at least two barrels to swap, a couple have 3 different bolt with the 3 "normal" size bolt heads, one Ruger receiver has 5 barrels and one Rem SA has two barrels and they all can be done in the field just as easy as in my home shop....and that's not counting ALL the swap barrels I have standing around in corners I made up for specific reasons that won't ever get used again.
No matter if it is NEF, T/C or a bolt gun, if you have the correct setup, swapping barrels is quick and easy, and all present their separate problems that need solving.
Most of my NEF's are dedicated to one barrel and as alluded to already...it is almost cheaper just to buy a new one than pay the barrel swap and shipping charges....the difference between buying a complete NEF in 500 S&W cal and sending a frame in to have it swapped out was 7 bucks more for the new rifle...that was a quote from my local Bimart...no contest there.
I've never been married to ANY one brand of ANYTHING...guns, trucks, cars, m/c's, women, tools, etc, are just tools to me and I don't measue myself by ANY of my toys...but if you're enamored by something, I see nothing wrong in it.
A shiny car, beautiful woman, fancy gun are all "Things of beauty and joys forever" as Keats put it...just some of us are junk yard dogs, like beer and pizza, while others are more fastidious and want a high rise apt champaign and caviar.
AND we all have opinions...

Luck