It is the peak pressure acting on the stationary bullet milliseconds after ignition that causes all the ruckus...this is a tube with one end closed with a moveable object(a bullet) and the other end close with a pressure transfering device(a case). There are specific "tube" formulas to calculate the instantanious pressures in the system. As the bullet progresses down the barrel the pressure is continually reduced even though it is still burning continuously and producing gas until consumed fully and it is expanding to fill the bore...a little bit of differential calculus or a Kinetic energy formula can give you the bullet energy number at various points along the length of the barrel.
I don't think the muzzle energy has anything to do with pressure on the standing breach at the moment of ignition...or I have a big problem with trying to use foot lbs of muzzle energy in the equation, two separate and distinct things are happening...that muzzle eneregy number is calculater AFTER the bullet leaves the muzzle or it can be calculated at any point that you know the bullet velocity...it has nothing to do with pressure generated by burning gas, THAT pressure is generated at the time of ignition BEFORE the bullet starts moving...THERE IS NO KINETIC ENERGY(energy produced by motion) AT THAT POINT...IT IS ALL POTENTIAL ENERGY(energy contained in the stationary object prior to motion) UNTIL AFTER the bullet starts moving...THEN the velocity is converted into kinetic energy...I know the bullet starts moving BEFORE the powder is completely burned...lets keep it simple. You're talking about overcoming the bullet inertia at the point of ignition and the amount of pressure transfered to the standing breach and other points on the frame...basically all 3 of Newtons laws acting in concert at different points in time...and the energy produced by the velocity and mass of a moving object at another point.
How much peak pressure is produced depends on a lot of factors...powder burning rate, friction of the type of bullet metal, bullet size in relation to the bore/groove, powder burn rate, the weight(mass) of the bullet and so forth. All of these factors are at work at the moment of ignition, and all of them have a basis in physics..which I'm still struggling to try to understand fully.
People are starting to play fast and loose with a lot of factors they really don't know a lot about, mixing apples with oranges again....like the metallurgy of the frame, hinge pin, barrel etc. NO ONE but NEF knows the exact formula of the metals or the "hardness". It doesn't matter WHAT the metal is called....1132, 4340, "ductile iron"...all those metal formulas have a range of tensile, compression, shear, etc strengths and can range from 45KPSI to 250KPSI for each designation. People, as usual, are lumping that information together without due understanding of all the facts...a dangerous thing to do.
As already alluded to, there CANNOT be any generalized answer to JUST WHERE, WHEN AND HOW MUCH pressure is exerted on WHAT part during the whole process without some very sophisticated measuring devices... and even then WHAT does it all mean?

...and just HOW useful is it to the average reloader.
It has been my experience with the NEF that the case will stick in the chamber or the action will lock up before you get into very much trouble...with the exception of the exceptions...you can definitely become coyote bait by EXCEEDING DESIGN PRRSSURES WITH THE LARGE DIAMETER CASES...
But in doing so you have broken ALL THE SAFETY RULES of reloading...START LOW AND WORK UP SLOWLY AND ....DON'T EXCEED DESIGN LIMITS.
I will use one more example...the 585 HE, I have one in my hot little hand that measures 0.633 at the base. Loaded to 15KPSI it will generate 4720psi which we assumed to be pushing against the standing breach. Due to the straight wall, strenght and thickness of the case it can be loaded to much, MUCH higher pressures without harming the NEF or putting too much more pressure on the breach.
Compare that to what the 30-06 does at 40,000 psi in my previous post.
Jack up the pressure in the 585 HE to 40KPSI and things change...the breach is now seeing 12,488 psi.!!! I'm not too sure just how well the NEF would handle this amount of case thrust OR how the pressures would be distributed...nor does anyone else until it has been tested and THEN ONLY for that specific rifle. Another rifle firing the same load might come apart.
Conjecture and opinion are great when tasting wines or how you like your steak, but in relation to the NEF frame I tend to think specific information from NEF should rule and the rest is just smoke and mirrors and walking TOO close to the edge of the unknown.
Luck