25 06 by far. I have owned most of the short mags and the return on investment is very minimal in relation to the standard cals and other mags. I think the 300 win mag is the best of the mississippi magnums for deer etc. I have used many 270, 06's, 243's,308, 7-08,and many others but by far the 25 06 is my choice for an all round caliber. I use the 120 gr PSP winchester load in mine and have shot many crows, coyote, deer, ground hogs and targets. This caliber in my Encore will shoot a small 3 shot hole at 100 yards and it opens up very little at 200. This is the most accurate gun I own and one of the most accurate I have ever shot! Very huge amount of killing power and very little recoil. I have found by shooting other 25's that they can be picky about their ammo, but, if you find one that shoots you will have a jewel.