Rick,
First off welcome to the forum and congrats on the new rifle! While I don't have a Handi in .22-250, I am interested in getting one. I may be wrong here, but I believe I remember reading a post in regards to neck sizing only with the .22-250 and I think there were some that had problems chambering rounds that were neck sized. I think as long as they chamber for you it should work out fine. I look forward to hearing how it shoots for you!
Don