Went out to my local dogtown today. Took a 223 a 22 rimfire, and my Ruger Blackhawk 357 6 inch. Killed several with the Blackhawk the farthest were 63 and 68 long steps. No scope. I found out one thing though, if the sun is glareing on your sights forget about any fancy shooting.
I'm shooting a 125 gr win hp in a 38 special case loaded to about 1100fps. A nice easy shooting load that shoots pretty straight.