JD Jones wrote an article in American Handgunner (July/August '01) listing advantages of jacketed bullets over hard cast bullets for hunting. Mark Hampton also writes about the advantages of jacketed bullets in his book Handgun Hunting ((pg 15). You won't find many people more dedicated to handgun hunting than those two.
With all due respect to JD Jones and Mark Hampton neither is a revolver hunter, sure they have killed a few animals with wheel guns but both are single shot handgun hunters that are shooting stockless rifles on 95% of their hunts. Hampton's book is little more than his bragging about his hunting exploits the world over, I have it, I have read it twice, It was barely worth the $5.00 I paid for it at Barnes and Noble's bargain bin.
Read Elmer Keith, read Ross Seyfried, these men hunted with handguns for animals they were not sure would die when they shot them. When Seyfried killed his first Cape Buff with a handgun in 1983 it was sticking his butt out on the line, now we think of it as pretty common practice. These men hunted with cast bullets because they work under all conditions for all game, they continued even after quality jacket bullets became readily available. When the chips are down a heavy cast slug can not fail, it will always penetrate, and it will kill. Jacketed bullets do a couple of things that are generally bad when it comes to killing game. They can fail because they are asked to change their shape in a controlled manner. Yes this causes more tissue damage but it also slows a bullet dramatically stopping the penetration that actually is the most important thing. Remember these guns start at a caliber that most rifle bullets will only barely attain when fully expanded, but they don't have the advantage of 3000fps to keep pushing the bullet deeper.
FA jacketed bullets to be fair will hardly expand if you it a anvil with them at 1500fps, they are thick jacketed and very tough, they are truthfully closer to a hard cast bullet than a jacketed bullet. If all you will hunt is a 125 pound whitetail a lighter jacket bullet will be fine, but if the the game is something heavy like moose, big bear, or elk then you really should have a heavy for caliber cast bullet in your gun.
Just my never humble opinion. Listen to Lloyd he is a wise man who has learned from some of the best...