You have picked a really good cartridge. Recoil is less every time you shoot it, so shoot cast 350's or 410's loaded down a little. My favorite jacketed bullet is the 350 Speer, holds together and penetrates well. The old Hornady 400 soft was a good bullet also, I've no experience with the new ones. My 410 gr. cast at 2200 fps does about all I need from this rifle. It is a comforting rifle to have in our grizzly infested hills. Most of them just woof and posture but some really have bad attitudes so...............
Mine weighes 9 pounds loaded and no scope of course. It will place two bullets next to each other every time I go to the range and see if the sights are still on. Most of it's shots are on rocks all over the desert and even rockchucks up high. The sights are by XS (rear) and NECG, which is a banded front with a sourdough brass face. Works very well and is on every time I pick up the rifle and never fogs. Yes, I am anti scope, remember all the old timers bragged how close they got when they made their shot.
Reloader 15, 4895, Varget, 4320 all work well. I would also sugest necking down 458 brass rather than necking up anything else. The 416 Taylor does make the 7mm and 300 mag useful, at least the brass can be necked up to 416.