I picked up a box a few years ago after purchasing a new Marlin with the "Ballard" rifleing.  I shot only one deer with the load-an average sized doe.  Unfortunately, I was too close (less than 50').  In my haste, I missed tucking the shot behind the shoulder and got the shoulder instead.  My poor marksmanship combined with the rather soft slug and close range ruined a great deal of venison.  I concluded that for my purposes (mostly "woods hunting" with average shots less than 50 yards) the Remington 300 is just too soft.  (Then again, if I hadn't botched the shot (hitting the shoulder) the round may not have acted like an RPG.)
That's only one experience with one deer.  Perhaps others can shed a more positive light.  (On the plus side, the load has mild recoil and very good accuracy with my Marlin).