This is a great topic. I have an old Model 99 takedown made in 1921. I have shot several whitetails with it and just love it's nice size, weight and good accuracy.
I achieve 1" 3-shot groups routinely with the rifle and I probably could even tweek that a bit. I handload all of my ammunition for it. On my 250 Savage, typically I shoot modestly priced 100 grain Rem Core-Lokt bullets and IMR-4350 powder.
The 250 Savage to me is a great round. Light in recoil, reasonable power, and properly loaded will match or beat the now-famous 243 Winchester. This cartridge is also a nice piece of American sporting arm history. Go ahead and fire up that 250!
:grin: