I've had my .41 Black Hawk for a few years, and it's still my most accurate handgun, with least variation from chamber to chamber. Up until just recently, I had trouble finding brass and bullets, but it's worth the trouble. Try the Hornady 210 JHP w/ somewhere around 18 grns of IMR 4227. 18.5 grns gave me my lifetime best 100 yd group (2"). That probably doesn't seem like a great group from the perspective of your .221, Fireball, but for open sights I'll take it. I've used HS-6, too; especially with cast bullets. I've used Laser Cast and Meister in 210-215 weight range with good results, and even cast my own using the LEE tumble lubed bullet. If you're tooling up to reload this one with cast bullets, I suggest a Lyman M die. It comes in the carbide set, or you can buy it for $10. Good luck.