I have a Winchester Model 70 in .416 Remington Magnum. I've found a good practice load using 72.5 grains of IMR-4895 and the 350 grain Speer Mag-Tip. This load chronographs close to 2,450 fps and should be good for moderate-range hunting on anything less than the big bears. Interestingly, I've seen loading manuals list as high as 77 grains with this powder/bullet combination but I think that recipe would be too hot for my rifle.