"One has the same dilemma with a cannon and maximum load that one does with a submarine and maximum safe depth.
Same issues. How do you test it without destroying it. How do you KNOW!? "
The difference is that the sub designers know what the water pressure is at any given depth and can do the math to determine how a design will react to that pressure. In our case, the chamber pressure is the thing we do not know and therefore doing math is irrelevant since we don't know what forces we are trying to resist. And unlike water pressure, chamber pressure is a function of chamber dimensions, powder type, granulation, charge weight and projectile weight plus a number of lesser factors. So without determining the chamber pressure for the specific combination of factors we are using, we are left quoting numbers generated from more or less (mostly less) similar experiments.
Besides, the maximum SAFE depth/load is one that gives a safety factor that allows for minor errors without causing catastrophic failure, not one that is one foot short of crush/one grain short of bursting.