I don`t load much .45 Colt ammo, just don`t shoot it. For my .44 mag`s. I like Serria bullets better than anything else, mostly 240 gn. HP`s. For my .454`s I shoot mostly Hornady XTP bullets as the Serrias are to soft to hold up to the velosities. I think that as far as accuracy goes, the Serrias and the Hornadys are both excellant. The Serrias definately expand alot faster than the Hornadys. I would say the Serrias for the .45 colt for hunting deer, and the Hornadys for hot loads for bear.