The last four whitetails I've killed have been put down by a 260 Rem 24" barrel, Encore. I use a 100gr Hornady SP in front of 43.5 gr of W760. All four were lung shots. Shortest run was 25 yards, longest was about 200. All were lung shots and all were through and through. I don't think I even got a rib bone with any of them. Sometimes it's a hassle to track them down with a lung shot and on my property they tend to run down in a pretty deep hollow on one side or the other. The upside is, I don't lose any meat to a bloodshot shoulder. I'm thinking that if I take a shot on a large buck I'll choose the shoulder and put him down right there. The 260 is my favorite round for the Encore. Low recoil, not very loud and very accurate. This load will easily do sub moa and I have done less than 1/2".
Rick