JimmyP50,
If I read your pot correctly, you want the airweight S&W 625 .45 ACP?
I have not seen the new gun yet, but think that would be the "N" frame stainless with round butt and shorter, lighter barrel?
If only the barrel is shorter, thinner, and lighter, I would have no reservations in shooting standard or warmish .45 ACP loads in it.
A lighter barrel would make the gun kick more, but does not affect it's durability. The frame, cylinder, and stressed components are the same as the full-size model.