Don't wory about the 22" barrel. You won't lose enough velocity to worry about bu the missing 2" make it a MUCH handier rifle. My .257 Roberts has a 22" barrel and I'm pushing 75g Hornady V-MAX at 3600fos and 115g Barnes TSX at 3000fps - the .25-06 should do that with ease even with a 22" barrel.
My point exactly, at the shorter barrel length you are just wasting the 25-06's potential, a 257 Roberts would be a better choice in that length IMO. Don't get me wrong I LOVE the 25-06 and I really like the mountain rifle but I don't think that they are the ideal pairing. If a mountain rifle makes it into my collection it will most likely be a short action with a smaller capacity case such as the 257 Roberts (you listening Remington?), a 260, a 7mm-08 or even a 308.
The 25-06 will work, and work well in that rifle, if you like both then by all means pick it up. Just not MY particular taste, buy what suits YOU not me. You asked for negatives and that is really the only one I can come up with. Many would agree that it is more of a nitpick than a negative. Rifles choice is often a matter of personal taste, this is a perfect example.
:wink: