I'm into the BIG MAGNUM myself, I shoot a 338/378 Weatherby. Love knocking Moose down at 800+ yards. But I am also into shooting subsonic. I have a 30-06 with a suppressor, and am loading Trail Boss. I have loaded up some 165gr Sierria HPBT backwards, will go to the range next week and try them for accuracy.
My partner and I have been working on .223 loads that are around 1900 fps, to try and slow them down so we don't blow foxes in half yet have enough to take down Coyotes, and maybe even a Wolf. He wants to stay with the .223, but I think this .300 Blackout may be a better way to go.