222 Rem rigs are still readily available, lots of them out there used in great condition at the very least, so they are still a very good choice to start with if you reload. If you don't reload the 223 Rem will get you by, but they give up precision to the Triple Deuce when dotting "eyes" hunting. And don't forget the 17 Rem, or when the ranges are longer the old 22 Varminter (22-250 Win). Nor the once wildcat cartridges that now have commercial versions. Many of them are good starting places for P&V. If you reload the skies the limit in wildcats for P&V as well, and they far outshine their parent counterparts.
There are occasional/opportunistic P&V hunters, P&V hunters, and serious dedicated P&V hunters. The tools and abilities for each level are not the same. There also are short range shooters, mid range shooters and serious long/extreme range shooters that also each require different tools and abilities. You can choose to get by with much less, find a happy medium or go all the way IOW, with the end results fitting the level shooter and equipment are capable of. So first up is deciding how far you think you might want to take P&V, how much you can afford in time, effort and money to gear up for it. But always buy the best you can afford, even if you have to save up for it, and it will be the cheapest choice for you later.
Probably the best choice is to start on page one, progress in time, effort and expense as you gain experience if it turns out to be your thing. It should fit what fits you, what you have the most confidence and ability for, what you get the most enjoyment out of. But as I learned a long time ago, buying "right" from the start will save you a ton of money later if it does become your main interest like it did mine for over 50 years. And the better equipment helps along your abilities, and so your confidence much faster simply because they perform for you better.
Junk has no place in the killing fields for an ethical hunter, especially when the ranges get long and the targets small. Nor does factory ammo for any cartridge that you can improve on by reloading it yourself. Not much you can do about the rimfires other than going to the 17's (that are excellent for P&V), but everything else can be tuned to your rig and will out perform factory fodder in it if you reload. Half MOA at 100 yards might be an acceptable starting place for P&V for some folks, but you get more and more out of the game the farther you shoot faster than with a rig that will honestly shoot quarter or better MOA. Half MOA isn't even an acceptable starting place for serious target shooting, good enough for plinking though maybe.
FWIW -YMMV