If you already have a 45, the one that makes the most sense would be the 357, after all, the only animal of size you would shoot is a deer, and that season lasts a few weeks at best. For anything else the lighter faster load of the 357 would be cheaper and better, The 357 will take deer out to 100 yards with any care in shooting, and coyotes and varmints to 150 possibly. It is also cheap and easy to load.