I put a T/C Renegade .50 cap lock together while I was in grad school.  That was 30 years ago.  I've used this rifle to put a lot of venison in the freezer (though not for a few years).  I ultimately decided on this working load:  90 gr. Goex FF/370 gr. Maxiball lubed with "Bore Butter".  When seating the bullet, you can feel loose spots in the barrel, at least that's the way I interpreted the places where the Maxi would "fall" and then stop until the ramrod fully seated the load.  I've also noticed that this particular gun doesn't do well with a clean barrel.  Again, I've assumed the fouled barrel sorta filled in the loose places.
I missed the last deer I shot at (with an unfouled bore).  Miraculously, I was able to get another chance at this uneducated doe, and the fouled bore printed according to the sight picture.  Could I have flinched?  (Who ME???).....Well, sure I could have, but I don't think I did.  Anyway, the end result plays havoc with my confidence in the rifle.  If I take the time to foul the bore, it reliably prints where it looks.  Guess I can do that.  (Like the patient who tells his doc, "It hurts when I do this."  And the doc replies, "Don't do that!")
Has there been chatter about irregular Thompson barrels?  Just curious.
Guess I should also confess, I've allowed my lack of confidence in the Renegade to excuse the purchase of a .54 T/C Hawken in nice, "pre-owned" shape.  I'll be curious to see how the bore in the new (to me) rifle compares with my Renegade.
PC