I'll bite........
Everything I have, and have had in over 30yrs. of messing about handloading, has responded to downloading. I have done most of this with cast lead bullets, plain base, where high velo can be problematic with my basic, cheap & easy WWt alloy.
The real issue with the H&R 44M barrel may well be the slow twist, downloads often need extra rotational speed to stabilize, as does longer/thus heavier, bullet design. If you arent getting groups with your download, try a shorter bullet. If cast, make sure it's dia. fills the throat, regardless of the barrel groove dia. (most throats are at least groove dia., if yours isnt that is a whole nuther problem). Jacketed is more forgiving, but it is still best to fill up the bore to prevent gas cutting of the grooves getting past the bullet sides. At least they dont 'strip' the rifling or lead, so many like using them; for me, I cant afford them. My old Shikari 44M shot everything from RB plinkers on up to full house factory magnums and it had the 'slow' twist, IIRC.
I guess the reason for the long case might be to make a 'more efficient' cartridge compared to the 444 or 45-70 , more akin to the 45ACP vs the 45Colt. It seems that higher pressures and more felt recoil is part of the result?
If I wanted a 'flat' shooter there are a whole bunch of better cartridges than these brick throwers, but I do like big bores.
I think if you have a good chamber with a decent throat and leade into the rifling, and a decent bore, you should be able to make it shoot slow or fast, it just may take a little more fiddlin' with the bullets.