87 grain Speer TNT in front of Reloader 19 for 3500fps and it's a coyote getter. I have a large bobcat mounted and it was shot at about 60 yds. No exit hole. I have shot the 2506 since 1971, in 7 different rifles. Everyone of them were one holers at 100yds, and I enjoyed them all, and of course I reloaded for them all. They are sensitive to overall length, meaning you had better not have the bullet shoulders touching the lands and grooves or you will get a face full of gas. The chamber pressure will skyrocket with such an event, but otherwise, it will shoot with any 270, and the even the 22250 at "way out there" ranges.
It is inherently accurate, and so much so, that it is occasionally used at Camp Perry matches for long range.