Getting in a bit late on this one.
Lots of great info.
As Alan said, having threads cut to match the action matter a great deal. The sooner the barrel has limited wobble when you are screwing it in the better. Hit the threads with anti gall compound too.
At the very least, true out the part of the barrel that butts against the action. Face off the action in a lathe, and you will have a perfect fit between the two. In many cases you can do this by only removing a few thou.
I know that it requires a little lathe work but it is worth it. As you can guess, too much to true it out and the chamber needs to be lengthened.
Definately go for the witness mark as well.
If you have the metal to work with, cut a flat under the chamber and use an adjustible wrench or a spanner to give it a couple extra ft lbs.
I had three trued barrels in different calibers (.225, .250imp, 308) and they all fired within 8" of each other at 100. Go figure.
I took one M48 in .450 marlin and ran a thumb screw with a rounded profile through the left reciever. Not horribly obtrusive and it works well keeping the barrel in place without a wrench.
Hope that helped.
Cheers
Tom