Started using a Lee Loader back in the 80's because I couldn't find a die set for the Win .225. (Did later)
Used Lee Loaders there after, when ever a new caliber happened to show up.
The only problem was some range picked up brass for the 7mm Mag, guy was shooting it out of a BAR.
Had a few cambering problems, but as the cases weren't trimmed, I suspect the problem was length.
Mostly now I just use the Challenger Press(s), but still have all the Lee Loaders, even found one for the 12 ga (not made anymore), just for 12 ga slugs.
I like the slow and steady, double check each step, method as well, and it is relaxing.
Haven't purchased a turret press yet, and probably won't unless I decide to mass produce one cal of pistol ammo.
As far as the Handi's go, the 45/70 seem to shoot well, and haven't had a problem with extraction.
The re-loaded brass was fired in the same rifle, as the first time, but I did check and trim the cases, not much on the first go around.