With all the talk of these big bore revolver rounds, buffalo cartridges, and wanting flat trajectory, the .357 Max is the clear choice in a 14" TC with the 180gr Hornady SSP bullet that is purpose designed for the velocities it will be used at. It's still going over 1400fps at 200 yards with sufficient energy for a clean kill, I'd still want a broadside shot at that distance. Zeroed at 150 yards, it's about 5-6" low at 200 yards and never exceeds 3" above line of sight. Couple that with moa accuracy and moderate recoil and there is no other straight walled round that gives it any competition, unless it's a .375 Winchester, but even that doesn't shoot as flat, and it kicks a bit more. A 14" TC with a 2x or 4x Leupold is a not that much of a load to carry in the field, certainly no worse than a long barrel revolver with optics that are needed for shooting beyond 50-100 yards. The only catch is that you have to be a handloader to utilize this round to it's full potential. If you shoot silhouettes, you know how effective this round is.
AA1680, Lil'gun, H4227, H110, all work well in this cartridge and will get you 1900-2000+ fps with the 180gr SSP.