Easily, the 375JDJ is a Contender round which is not as strong as a Handi which comes factory chambered in 500S&W and 270 Win to name a couple high pressure chamberings you'll never see in a Contender. There are no drop in barrels for an H&R tho, the only way to get there is to rebore and rechamber an existing barrel, or have a stub made, either of which will cost $300 plus the cost of the donor parts.
Tim