Practice. If you don't reload you better have deep pockets, then it is still not all that cheap with the price of things today. Practice in "field position". Shoot in all of the ways and off of what you think you might use as a rest. I have seen this happen over and over, Guys go to the range, put the bags up on the bench. Shoot a few groups and call it good. Then go and shoot out of a tree stand or try and shoot from akneeling or sitting position and have a bad shoot or miss. Then it is the gun or the ammo being the problem. Rifles are a bit more forgiving than "buttless" guns.
As to caliber you mentioned the 243 or 308 being a thought. I myself shoot a 308 in an encore hand held platform and it does have a scope on it, 2-6 bushnell. Bullet selection and performance in the 308 is a lot better ,imho, than the 243. I have not looked for any 308 ammo, but, have heard it can be hard to find and pricey. I wouldn't turn up my nose at a 30-30 either. Factory ammo will perform as well as it does in a rifle, and it may be a bit easier and cheaper to find.
I started off handgun hunting because I disliked archery. First handgun was a SW 29 44 mag, witha 10 5/8" barrel. I killed a lot of deer with that and iron sighted. I had guys make the comment that it wasn't a handgun. Then I went to TC's and was making longer connecting shots on deer than they could with their rifle. It was a 30-30 so much for the myth that a 30-30 pretty much just stops and falls to the earth past 100 yards. Most shots were 200-250. It was getting shot right around 100 rounds a month, along with some other shooting too. Then I got back to rifle hunting.................sorry killing. I was fooling around with a 25-06 and needed to cull some deer. There was just no way to get into any kind of close range, short shots were 300 yards, with most being around 400. That isn't hunting that is just killing, imho. Now, I have come full circle and bought a bow. I have yet to "harvest" a deer with this and this coming fall will be my first attempt.
BTW, I have already been told this isn't bow hunting as it is a compound with a peep and pin sights.
I figure a true sportsman will use what is available to help him do his best to cleanly take the animal he is after in humane way and not try to over do his know ability. If we didn't all up grade we would still be running buffalo over cliffs and chunking rocks and spears.
jeff