I have been loading for a Guide Gun in .450 for years, and it will do anything that I could ever ask on this continent. Ilove the round, but for a bolt gun, and more power, why not a .458 WIN ? I mean, from my perspective, if I need more power than I can get from my Guide Gun, I'm going after African dangerous game, and would step up to a magmum of some sort, but that's just me