Back before 180 grain bullets became popular, and available I read that a good cast 158 grain bullet at 1100 fps would do all that a .357 mag was going to do. I expect that a 180 will do a little more. I've only shot one deer with a handgun, and that was with a .38 Special using the Speer 146 gr half jacket hp. He didn't go anywhere when I broke his neck. A hard cast bullet of reasonable weight out of a .357 mag will out penetrate a fmj out of a .45 acp every time, so size isn't everything. When we talk about the .41 Mag, I think the guns used are more important than the caliber choice. I carried a .41 Blackhawk in the woods a lot in my younger years because it was so much lighter, and handier than my .44. In the S&W I really see no point in carrying a heavier gun to use a smaller caliber. Actually, with strong guns, and what is available today, there isn't much point in listening to, and enduring the muzzle blast of a .44 Mag when a .45 Colt will do the same thing, or better, and is much more pleasant at 10,000 psi less. (now that is bound to be a popular statement) By the way, I currently own .357's, and .44 mags. Ideally, I would have a .357, or .38 Special, a well made, and light .44 Special, and a .45 Colt for the heavy stuff. Too bad the gun companies don't see it that way.