Well, my intent to build a 700-800 yard elk rifle in .338-375 Ruger custom has fallen by the wayside for a number of reasons.
The first is practicality.  I don’t really NEED such as rifle, as I already have a perfectly good .300 Win Mag that will suffice.  Another is that the Interarms Mark X action I have is made for a .30-06 size cartridge and I’d have to get the bolt face and feed rails modified – no big deal in the greater scheme of things but unnecessary if I go with a .30-06 or one of its many siblings.  Then there is the cost of shooting – the cost of .338 plinking bullets would be about double that for a .30 or under, brass costs would be more and the .338-375 Ruger would consume more powder. Then there is the issue of forming brass.  While none of these were show-stoppers, there was another and more important issue  - l decided to build a rifle my daughters would be comfortable shooting, which meant a .30-06 or smaller.  Since there are already multiple .30-06’s in the safe I decided a sub-.30 would be the way to go.
The goal was still to have a rifle capable of 700-800 yard shots on deer and antelope if needed but more importantly be capable of 500-600 yard shots at the range.  Specifically, I was looking for the best balance of trajectory, retained energy, recoil and powder efficiency.  The ballistics for a number of cartridges were investigated with a variety of bullet weights and types in each cartridge.  The cartridges studied included the .257 Roberts, .25-06, .257 Weatherby Magnum, 6.5mm-06, 6.5mm-06AI .264 Winchester Magnum, .270 Winchester, .280 Remington, .280 Remington AI, 7mm Remington Magnum, .300 Win Magnum and the previously intended .338-.375 Ruger (using .340 Weatherby data).  Since I already have a .257 Roberts, 7mm Remington Magnum and .30 Winchester Magnum they were used for comparison purposes only but were not candidates for the new rifle.
What I found was the 6.5mm-06 and 6.5mm-06AI with 120 Ballistic Tip and 130g Scirocco bullets did very well.  They shot nearly as flat as the .257 Weatherby 110 AccuBond and  flatter than the .257 Weatherby with 120g Partitions but offered more downrange energy, burned less powder and generated less recoil. The 130g Scirocco was just behind the 7mm Remington Magnum in terms of trajectory and energy, but again burned less powder and generated less recoil.  Estimates for the 6.5mm-06 Ackley Improved, using up to 10% more powder and generating 3% more velocity, are even more impressive in terms of trajectory and energy and still provide better powder economy and generate less less recoil than the other loads.  (The 6.5mm-06 AI/130g Scirocco actually beats the 7mm Rem Mag 140g AB load at 800 yards in terms of both trajectory and energy – at least on paper.)
For a couple of reasons, I am leaning toward the 6.5mm-06 Ackley rather than the standard version.  The primary reason for this is that I could use inexpensive .25-06 brass without fear that someone might chamber a loaded cartridge in a .25-06 rifle.  The additional velocity provided by the AI version is tempting but I might find myself loading to standard 6.5mm-06 velocities and reaping the benefits of lower pressure and longer barrel life. 
Below are some of the comparisons I ran using “Point Blank” ballistic calculator (available free at 
www.huntingnut.com).
A few notes on the data:
1. Most velocity data is from Nosler 6th Edition.  Some are estimates or are from other sources.
2. In some cases bullets have been changed from that in the data books – notably for the Scirocco, but also for the TTSX.
3. Manufacturer Ballistic coefficients have been used when available.  In some cases they are estimated.
4. Recoil data is calculated for a 8.3 pound rifle and scope combo.
5. MPBR (Maximum Point Blank Range) is calculated for a maximum rise or drop of 3” from Line Of Sight (6” diameter target). 
=============================================================
Name: .257 Roberts, 100g TTSX
Ballistic Coeff: 0.418 (estimated)
Bullet Weight: 100
Velocity: 3250
Target Distance: 270
Powder charge: 48g
MPBR: 317
Recoil: 12.2fpe @ 9.7fps
Ballistic Data
~~~~~~~~~~~~~~~
  Range  Elevation  Velocity   Energy  10mph Wind Deflect
  0 yds   -1.50 in  3250 fps  2345 fpe    0.00 in
300 yds   -1.81 in  2591 fps  1491 fpe    5.91 in
400 yds  -11.26 in  2392 fps  1270 fpe   10.80 in
500 yds  -26.94 in  2201 fps  1076 fpe   17.64 in
600 yds  -49.70 in  2019 fps   906 fpe   26.40 in
700 yds  -80.85 in  1846 fps   757 fpe   37.35 in
800 yds -123.07 in  1685 fps   631 fpe   51.30 in
=============================================================
Name: .257 WBY 110g AB 
Ballistic Coeff: 0.418
Bullet Weight: 110
Velocity: 3480
Target Distance: 289
Powder charge: 71.0g
MPBR: 338
Recoil: 19.6fpe @ 12.3fps
Ballistic Data
~~~~~~~~~~~~~~~
  Range  Elevation  Velocity   Energy  10mph Wind Deflect
  0 yds   -1.50 in  3480 fps  2958 fpe    0.00 in
300 yds   -0.58 in  2787 fps  1898 fpe    5.38 in
400 yds   -8.46 in  2579 fps  1625 fpe    9.93 in
500 yds  -21.46 in  2380 fps  1384 fpe   15.99 in
600 yds  -40.79 in  2191 fps  1172 fpe   24.03 in
700 yds  -67.23 in  2009 fps   986 fpe   33.97 in
800 yds -102.25 in  1837 fps   824 fpe   46.15 in
=============================================================
Name: .257 Weatherby 120g Partition
Ballistic Coeff: 0.391
Bullet Weight: 120
Velocity: 3427
Target Distance: 250
Powder charge: 70.0 (estimated)
MPBR: 330
Recoil: 20.9 @ 12.7fps
Scope Height: 1.500
Temperature: 70
Altitude: 500
Ballistic Data
~~~~~~~~~~~~~~~
  Range  Elevation  Velocity   Energy  10mph Wind Deflect
  0 yds   -1.50 in  3427 fps  3129 fpe   -0.00 in
300 yds  -2.70 in  2699 fps  1941 fpe    5.94 in
400 yds  -11.73 in  2481 fps  1640 fpe   10.94 in
500 yds  -26.40 in  2273 fps  1377 fpe   17.73 in
600 yds  -47.92 in  2076 fps  1148 fpe   26.69 in
700 yds  -77.22 in  1888 fps   950 fpe   37.76 in
800 yds -117.09 in  1713 fps   782 fpe   51.91 in
=============================================================
Name: 6.5mm-06 120g BT
Ballistic Coeff: 0.458
Bullet Weight: 120
Velocity: 3294
Target Distance: 276
Powder charge: 55.5g
MPBR: 324
Recoil: 16.4fpe @ 11.3fps
Ballistic Data
~~~~~~~~~~~~~~~
  Range  Elevation  Velocity   Energy  10mph Wind Deflect
  0 yds   -1.50 in  3294 fps  2891 fpe    0.00 in
300 yds   -1.38 in  2683 fps  1918 fpe    5.26 in
400 yds  -10.21 in  2497 fps  1661 fpe    9.65 in
500 yds  -24.52 in  2318 fps  1432 fpe   15.48 in
600 yds  -45.51 in  2147 fps  1229 fpe   23.22 in
700 yds  -73.96 in  1984 fps  1048 fpe   32.76 in
800 yds -110.98 in  1827 fps   889 fpe   44.27 in
=============================================================
Name: 6.5mm-06 130g Scirocco
Ballistic Coeff: 0.571
Bullet Weight: 130
Velocity: 3151
Target Distance: 270
Powder Charge: 55.3g
MPBR: 318
Recoil: 16.6fpe @ 11.3fps
Ballistic Data
~~~~~~~~~~~~~~~
  Range  Elevation  Velocity   Energy   10mph Wind Deflect
  0 yds   -1.50 in  3151 fps  2866 fpe   0.00 in
300 yds   -1.79 in  2670 fps  2057 fpe   4.37 in
400 yds  -10.94 in  2520 fps  1833 fpe   7.94 in
500 yds  -25.51 in  2376 fps  1629 fpe  12.69 in
600 yds  -46.41 in  2236 fps  1443 fpe  18.92 in
700 yds  -74.29 in  2101 fps  1274 fpe  26.59 in
800 yds -109.83 in  1971 fps  1121 fpe  35.70 in
=============================================================
Name: 6.5mm-06 Ackley Improved 130g Scirocco
Ballistic Coeff: 0.571
Bullet Weight: 130
Velocity: 3245
Target Distance: 278
Powder Charge: 60.8g
MPBR: 327
Recoil: 19.2
Scope Height: 1.500
Temperature: 70
Altitude: 500
Ballistic Data
~~~~~~~~~~~~~~~
  Range  Elevation  Velocity   Energy   10mph Wind Deflect
  0 yds   -1.50 in  3245 fps  3039 fpe   0.00 in
300 yds   -1.24 in  2754 fps  2189 fpe   4.20 in
400 yds   -9.73 in  2601 fps  1953 fpe   7.69 in
500 yds  -23.27 in  2454 fps  1739 fpe  12.25 in
600 yds  -42.59 in  2312 fps  1543 fpe  18.12 in
700 yds  -68.62 in  2174 fps  1365 fpe  25.51 in
800 yds -101.83 in  2041 fps  1203 fpe  34.27 in
=============================================================
Name: 7mm RM 140g AB
Ballistic Coeff: 0.485
Bullet Weight: 140
Velocity: 3340
Target Distance: 282
Powder charge: 67.5g
MPBR: 331
Recoil: 23.5fpw @ 13.5fps
Ballistic Data
~~~~~~~~~~~~~~~
  Range  Elevation  Velocity   Energy  10mph Wind Deflect
  0 yds   -1.50 in  3340 fps  3468 fpe    0.00 in
300 yds   -0.99 in  2755 fps  2359 fpe    4.84 in
400 yds   -9.29 in  2576 fps  2063 fpe    8.88 in
500 yds  -22.72 in  2404 fps  1797 fpe   14.20 in
600 yds  -42.31 in  2239 fps  1559 fpe   21.21 in
700 yds  -68.88 in  2081 fps  1346 fpe   29.91 in
800 yds -103.11 in  1928 fps  1156 fpe   40.27 in
=============================================================
Name: .300WM 165g AB
Ballistic Coeff: 0.475
Bullet Weight: 165
Velocity: 3290
Target Distance: 277
Powder charge: 79.0g
MPBR: 325
Recoil: 31.9fpe @ 15.7fps
Ballistic Data
~~~~~~~~~~~~~~~
  Range  Elevation  Velocity   Energy  10mph Wind Deflect
  0 yds   -1.50 in  3290 fps  3965 fpe    0.00 in
300 yds   -1.31 in  2700 fps  2671 fpe    5.06 in
400 yds  -10.01 in  2520 fps  2326 fpe    9.23 in
500 yds  -24.13 in  2347 fps  2017 fpe   14.84 in
600 yds  -44.75 in  2181 fps  1742 fpe   22.24 in
700 yds  -72.53 in  2021 fps  1496 fpe   31.29 in
800 yds -108.63 in  1868 fps  1278 fpe   42.24 in
=============================================================
Name: 300WM 180g AB
Ballistic Coeff: 0.507
Bullet Weight: 180
Velocity: 3160
Target Distance: 268
Powder charge: 73.0g
MPBR: 315
Recoil: 31.8fpe @ 15.7fps
Ballistic Data
~~~~~~~~~~~~~~~
  Range  Elevation  Velocity   Energy  10mph Wind Deflect
  0 yds   -1.50 in  3160 fps  3991 fpe    0.00 in
300 yds   -1.94 in  2620 fps  2744 fpe    4.96 in
400 yds  -11.39 in  2454 fps  2407 fpe    9.01 in
500 yds  -26.63 in  2294 fps  2104 fpe   14.54 in
600 yds  -48.64 in  2140 fps  1831 fpe   21.76 in
700 yds  -78.20 in  1993 fps  1587 fpe   30.66 in
800 yds -115.98 in  1850 fps  1368 fpe   41.16 in
=============================================================
Name: .338-375 210g TTSX
Ballistic Coeff: 0.482
Bullet Weight: 210
Velocity: 3223
Target Distance: 272
Powder charge: 83.5g
MPBR: 319
Recoil: 43.6fpe @ 18.4fps
Ballistic Data
~~~~~~~~~~~~~~~
  Range  Elevation  Velocity   Energy  10mph Wind Deflect
  0 yds   -1.50 in  3223 fps  4843 fpe    0.00 in
300 yds   -1.66 in  2649 fps  3273 fpe    5.11 in
400 yds  -10.80 in  2474 fps  2853 fpe    9.33 in
500 yds  -25.60 in  2305 fps  2477 fpe   15.01 in
600 yds  -47.13 in  2143 fps  2141 fpe   22.49 in
700 yds  -76.15 in  1987 fps  1841 fpe   31.71 in
800 yds -113.60 in  1838 fps  1575 fpe   42.72 in
=============================================================