I see how the last thread applies to the topic. I once met a guy from buffalo, but you don't see me writeing about it.
Like any premium ammo, you have to weigh the performance need with the hunt. For deer, black bear and typical big game, the leverloution is probably the best value around.
The buffalo bore is meant for big big game (big bears, africa, etc). You probably will never require the edge the heavier hot loads will provide with average game.
I hand load 405GR REM to about 100FPS out of a guide gun, and it hass shot shoulder to shoulder bone and all in black bear. The 405Gr factory load is a penetrator, but pretty dismal performance becasue of the low power specs of BP pressure. The 300gr stuff is crap. it will act like a 12g slug, lots of expansion and damaged meat, not much penetration.