I have a Vanguard sub moa and I have to say that I really love that rifle. I hunted with it a lot last year and a fair amount the year before. 2 years ago, most of my shots were right at or under 100 yards. Both deer fell pretty much where they stood when hit. Last year I took 2 within 100, one at 180 and one at 280 yards. I was shooting 115 gr ballistic tips in factory ammo because I have not yet duplicated factory ammo in this caliber. I was originally shooting 120 Partions but I ran into a problem of deformed tips from the recoil in a relative light rifle. The only deer that has required any hold over at all was the one at 280 and I only held a couple of inches higher than I normally would. That deer spun around as if hit by a sledge hammer, took 2 steps and fell. I own several rifles in 257, and I can honestly say that the Weatherby is the king of them. You pay for the performance in recoil and the expense associated with powder and brass but if you are planning on long shots, it is worth it. There is no problem with a 25/06, it is a great round but past 250 I would prefer to have a weatherby. On the other hand, for soft recoil and shots under 150, I would prefer the 257 Roberts. My daughter will be shooting the Bob this year. She will be limiting her shots to 100 or less but the rifle is capable of much more. Good luck and remember, You can load a weatherby down to 25/06, in fact that is the best that i get with my loads, but you can't load the 25/06 up to the weatherby.