I'm not aware of any major differences between the two calibers. My wife loves her .270 and I my 7mm-08. I think, perhaps, the accuracy and reliability of the two is a draw. If you're not reloading, look at the factory loads available and go from there. I like both of them, and would be happy with either. If I couldn't have either, I'd have my .308. IMHO, it is better than both. It's not as "flat shooting", but it is extremely accurate at close or long range, and kills when it gets there. But then, my Handi .45-70 does the same thing, as does my '06. I think any of these Handis will, or can be easily made to perform well. It's just a matter of your choice.