This copied from the Hodgdons ONLINE reloading data for the "modern rifles" of 45-70 caliber.
300 GR. SIE HP IMR IMR 4198 .458" 2.525" 54.0 2253 31,800 CUP 58.5C 2450 43,000 CUP
300 GR. SIE HP Hodgdon H4198 .458" 2.525" 59.5 2394 37,300 CUP 63.0 2532 50,000 CUP
350 GR. HDY JRN Hodgdon H335 .458" 2.540" 57.0 2016 32,200 CUP 63.0 2174 47,300 CUP
350 GR. HDY JRN Hodgdon H322 .458" 2.540" 52.0 1898 25,800 CUP 57.0C 2143 41,100 CUP
350 GR. HDY JRN IMR IMR 4198 .458" 2.540" 49.0 2118 37,700 CUP 52.0 2212 43,900 CUP
350 GR. HDY JRN Hodgdon H4198 .458" 2.540" 50.5 2104 35,100 CUP 56.0 2300 50,000 CUP
400 GR. SPR JFP Hodgdon H335 .458" 2.540" 54.0 1883 31,900 CUP 60.0 2057 49,800 CUP
400 GR. SPR JFP IMR IMR 4198 .458" 2.540" 47.0 1954 35,400 CUP 50.0 2089 47,100 CUP
400 GR. SPR JFP Hodgdon H4198 .458" 2.540" 48.0 1915 31,800 CUP 53.0 2108 49,100 CUP
Do with it what you will. To my thinking, many of these bullets will most likely fragment, at those velocities, upon hitting anything substantial. The 45-70 will kill anything on the planet, with the right bullet design and weight and at the correct velocity. Not always at the fastest possible velocity either.
When users of Garrett's ammo kill huge african animaks with a 530gr cast bullet at 1600fps, the point of pushing them higher is moot. most you'll get out of a 2400+ velocity with a 300gr HP is a flatter trajectory, but it will never be a 308 Win in that regard.