One of the most pleasing things about NEF single-shots is the easy cleanup chore after shooting. My Versa-Pack .22 needs nothing more than a few passes from the chamber end with a Bore-Snake, and a quick wipe of the inside of the frame, to call it clean and put it away. I do remove the barrel from the frame every time to make the job easier, but that is only one screw. Compare that with the work involved in properly cleaning a self-loader -- fouling all over the breech and bolt, and if you don't remove it, there's that "scritch-scritch" sound when you work the bolt, from fouling and oil and solvent circulating through all those moving parts. Nitro solvent followed by lots of sprayed brake cleaner makes it easier, but you better be careful with that stuff on plastic parts, and the finish on Ruger 10/22 receivers is softened by many Gun-Scubber-type solvents.
Quickdtoo stores his extensive collection of NEF rifles muzzle-down, and I have begun to do so, too. Pad the bottom of your storage area, and just stand the rifles on their muzzles. Oil and solvent, and any dirt they carry, drain out, and the locking lugs stay dry, contributing to consistent lockup.