Grains used to be a weight measure, in the 17th & 18th Centuries, but BP was pretty uniform, and very forgiving in accuracy, of small weight variations. So, BP grains became a VOLUME measure, which is what all the loose-powder measures are graduated in.
Smokeless is definitely a weight measure, which is why the powder measure settings must be checked with a scale. Smokeles is very "dense" in terms of energy, and minor variations in weight can take your gun (and maybe you) apart.
Most guys just fill the case up so that the charge will be at least slightly compressed, and set their measures for that amount. They don't know and don't care what the actual weight is.