I have owned both rugers and smiths, and with out a doubt, the smiths are a much nicer gun. They have better triggers, and are pretty much better all around. But this can be expected, as they cost more than a ruger. I am with graybeard on this one, and although I have only owned around 4 smiths, they all had great triggers. But don't get me wrong, all the rugers I have ever owned have been good guns. (mostly convertable-type) Now, all things aside, the only revolvers I own right now are colts, one annaconda, one python. Shoot one of these, and you will not want anything else. Again, you get what you pay for, and you can't touch a decent condition python or annaconda for less than a grand.
Sorry for my rant above. The caliber selection is easy. Because you don't reload, get a 44 mag. unless you like spending 30 to 40 bucks on 20 of the suped-up +P 45 loads, which gives you about the same performance as a standard 44 hunting load.