Montveil 
I am a lefty to, I own a 10/22 also, I have never heard of the safety being switch for us lefty's.  If I were you I would try the Ruger website, You could find something their or post this same question on the left hand shooters forum.  I really don't know because all I did was change the way I turned off the safety.    
Hope this helps 
Buckshooter