Well that short and fat is kind of comparatively. To a rifle bullet yes, but for a handgun, a 325grainer in a .45colt is a pretty big chunk of lead. You go up 50 more grains or so and you are filling the cylinder. Even in my .454, a 395 grainer goes right out to the end of the cylinder.
I have those 395 grain bullets going about 975, and they are some force to deal with, you could knock pretty much anything over with one of them. I wouldn't hesitate to bring them down another 100 to 150fps and still used them on medium sized game.
I have some 500 loads that use 400 and 300 grain bullets, they are more up around 1700-2000fps... but can be loaded down of course. The 300 grainers don't have that bad of accuracy, they aren't lead though, the are gold dot hp's, but still don't have too much length compared to a cast bullet of the same weight. I am in agreement thought that a 400 grain bullet at lower speeds is still going to do you better for stability at speed and accuracy.
If you put the two in the same equation:
This is a 300 grain bullet from a .500 caliber at 800fps.
Range Velocity Impact Drop ToF Energy Drift
0 800 -0.5 0 0 426 0
10 794 2.13 0.35 0.04 420 0
20 788 4.22 1.25 0.08 414 0
30 783 5.73 2.72 0.12 408 0
40 777 6.69 4.75 0.15 402 0
50 772 7.06 7.36 0.19 397 0
60 766 6.85 10.56 0.23 391 0
70 761 6.04 14.35 0.27 386 0
80 756 4.64 18.74 0.31 381 0
90 751 2.63 23.73 0.35 376 0
100 746 0 29.35 0.39 371 0
Same thing with a 400 grainer
Range Velocity Impact Drop ToF Energy Drift
0 800 -0.5 0 0 568 0
10 796 2.1 0.35 0.04 563 0
20 791 4.14 1.25 0.08 556 0
30 787 5.63 2.71 0.12 550 0
40 783 6.56 4.73 0.15 545 0
50 779 6.91 7.32 0.19 539 0
60 775 6.7 10.48 0.23 533 0
70 772 5.91 14.22 0.27 529 0
80 768 4.53 18.54 0.31 524 0
90 764 2.56 23.46 0.35 518 0
100 760 0 28.97 0.39 513 0
For either bullet there is going to be compareable trajectory within 100 yards, now this is sighted in at 100 yards, and to improve your holding even more, and if you knew you were so limited, you could even sight in a 50 yards, and have pretty much the same hold at any range within 50.
To easily see the energy, range, and trajectory, I used
www.handloads.com/calc