I am not a fan at all of point blank sighting in. If I have a gun I'm going to hunt with, I want to know exactly where it is going to hit at any range. If I take a shot, and it is 5" off, then I consider my shooting off, even if it is way out there.
I wont be aiming just for the "kill zone" on an animal. I will be aiming for a certain crease on the hair where I prefer to shoot, and at the range I am shooting, I want to know exactly how high or low I need to place my shot. IF you shoot your hunting rifle as much as you need, and at different ranges, then you will know what those differences are.
I don't think you correctly understand how Maximum Point Blank Range (MPBR) zeroing works, or at least not how it CAN be done. I zero all my rifles for MPBR for a 6" diameter target so the bullet is never more that 3" above or below line of sight from the muzzle to MPBR. If I'm 5" off the target its not because of the zero method. Further, I know the bullet drops because I verify it out to 400 yards, which is as far as my rangefinder goes. My range has just been reconfigured and I'll be checking drops out to 600 yards.
MPBR zeroing is no different zeroing for any other range except in the manner in which it is defined. For example, take a .300 Win Mag with 180g TSX bullets (B.C. .453) at 3038fps (my load). If you zero for 200 yards the trajectory is something like this:
200 yard zero (+1.5” @ 120 yards, -3” @ 258 yards)
+1.4” @ 100
+0.0” @ 200
-6.4” @ 300
-18.6” @ 400
-3.6” @ 500
If you zero at 250 yards (+ 2.8” @ 145 yards, -3” @ 298 yards):
250 yard zero
+2.4” @ 100
+2.0” @ 200
-3.3” @ 300
-14.5” @ 400
-32.5” @ 500
And if you zero at 300 yards (+4.5” @ 165 yards, -3” @ 338 yards):
300 yard zero
+3.6” @ 100
+4.3” @ 200
-0.0” @ 300
-10.1” @ 400
-26.9” @ 500
All of these give you a know trajectory, with varying amounts of mid-trajectory bullet rise. I prefer to use MPBR for a 6” target which means the bullet never rises more than 3”. That looks like this:
6” MPBR zero (256 yards zero, 301 yard MPBR, +3.0” @ 150 yards, -3.0” @ 301 yards))
+2.6” @ 100
+2.3” @ 200
-2.9” @ 300
-14.0” @ 400
-31.9” @ 500
To zero for MPBR zero range works out to be (256 yards in this example) is no trick, just look at the drop for 100 and 200 yards and adjust the scope accordingly. With this load, zeroing for 200 yards is just like MPBR zeroing for a 3” diameter target, zeroing for 250 yards is like a 5.6” MPBR zero and zeroing for 300 yards is like a 9” MPBR zero.
Again, there is no real difference in the two methods.