In case the OP is still keeping an eye on this thread...
I am not now and never was much of a pistol fan, but the 4506 was the first full-size .45 I shot. It left a favorable impression on me; a nice big, heavy gun that is very comfortable in my hand. I when out and bought a used one with a couple blemishes on the finish. It has yet to malfunction on me, with any of the extremes in commercial or hand-loaded ammo I've run through it. It's easy on my precious loadin' brass, and very accurate with the right loads.
The trigger is God-awful and to the best of my knowledge, can't easily be corrected.