I had the pleasure (adrenaline rush) of shooting my buddy's 458 Lott Ruger this weekend. In the past, I've been lucky to shoot several big bores including some 375s, 458 Wins, 460 Wthby, 405 Win, and 378 Wthby. I guess I should say that these are not bench guns and probabably should not be shot from a sitting bench. That said, one day in 1990 I shot a 1 1/2" group at 200 yards, 3 shots with the 378, and it was an exercise in willpower. The 378 was the worst in recoil in all those rounds by a fair margin, I believe because of the velocity.
If you shoot these guns from a standing position, offhand or with a standing rest, they are ok. The Ruger 458 Lott kicks, make no mistake, but from offhand, it was fun. We blasted some big holes in an oak stump, and we had alot of fun doing it.