Heres a good one.
1994 ford f250, long bed, 351w,5 speed, pulling a 1800lb trailer with a 4500-4700lb buick electra. 8mpg hauling this load to denver! Gutless on hills. Amazing how those big rigs hauling 40-50,000lbs get around 6-7mpg.
Know a guy who bought a 1978 chevy 3500, had a 454 and 4 speed, Hes a buick guy so he pulled the motor, built a fresh '69 430 buick bigblock, mated it to the 4 speed. Hes hauling his 16 foot covered trailer with all his tools, a 70 GS 455 "3600lbs" in the trailer and hes getting 14.5mpg in the mountains! How? Look up the Torque on a '69 430. Its all made at low RPM where as ford and chevy has always been in the 4000 rpm range VS buicks 2600-3000rpm range. He also put in an RV cam when he rebuilt the motor.
As for tire size, My 53 ford has a 3.89 ratio rear end, Put 14" Tires on, the final gear ratio works out to 4:11. Put a 15" wheel on and its back to 3.89. When you put in a low ratio gear like, 4.11 and top it off with a 31-33" tire, Those big tires tame the gears while helping you keep the RPM lower. Put your regular 15" wheels that came factory with those 4.11 gears and you'll be sucking more fuel than ever.
My 71 skylark is getting 3.73 gears but im going with 28" tires to keep the RPM's lower than if i went with a 26" tire.