Fred has it right. If you can't put the fired case back in the rifle and close the action you will have short case life. Handi's do not have very stiff actions so they allow the case to expand, and worse yet it lets the case expand more on top than on the bottom, so you end up with a case head that is not at right angles to the body. This ends up hardning the middle of the case which will lead to the case seperating part way up. This is really OK, because it still leaves the bottom part to seal the breach, so you probably won't get a face full of hot gas, but you still have to get the broken half out which will ruin your hunt or trip to the range. Load the 22-250 up about 4 times and dump the cases, brass is cheap for them. Larry