It would all depend on the load. Remington, Winchester, other wimpy loads, no way. Use the Hornandy Leverevolution, Garrett, Buffalo Bore, Corbon, all of which are pretty hot, then yeah, I'd take one at 300 yds with the right bullet. As long as the ammo, gun, and more importantly, I, are up to it. Lots of practice..... The problem with some of these loads is that you can't use them in the Contender, due to pressure and backthrust on the face of the action.